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The cumulative incidence of AFL with GLP-1 RAs was 8 per 10,000 patient-years
10.1258/ebm.2011.011152 Exp
Surely you MUST increase the dose
But it can take about a month to notice weight loss
CJC-1295 without DAC occupies the sweet spot: longer-acting than sermorelin (which degrades too fast for reliable clinical effect), shorter-acting than DAC (which sacrifices pulsatility), and considerably cheaper than tesamorelin (the only FDA-approved option in this class)
The Phase 2 trial (Jastreboff et al., NEJM 2023) identified gastrointestinal effects as the most common adverse events
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