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It does not mean the medication is failing

Effects of Tesamorelin on insulin sensitivity and cardiovascular risk markers. Diabetes Care

Theyre most effective when combined with healthy lifestyle changes, says Marlena Klein, DO , a board-certified internal medicine physician

Jastreboff et al., NEJM 2023), participants were assigned to dose cohorts of 1 mg, 4 mg, 8 mg, and 12 mg once weekly, with the 8 mg and 12 mg cohorts demonstrating the greatest weight-loss efficacy

Reaching 8mg comfortably produces better outcomes than trying and failing to reach 12mg

They get motivated and now they just cant get the medication, which is more devastating for their morale," said Rafi