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Notably, the IL-6 receptor itself lacks intrinsic signaling capacity and requires the binding of the glycoprotein gp130 to initiate intracellular signaling cascades [56]

Prkacin, I., Separovic, J., Aralicia, G., Perovic, D., Gjurasin, M., Lovric-Bencic, M., Stancic-Rokotov, D., Staresinic, M., Anic, T., Mikus, D., Sikiric, P., Seiwerth, S., Mise, S., Rotkvic, I., Jagic, V., Rucman, R., Petek, M., Turkovic, B., Marovic, A., Kokic, N

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Jornal Brasileiro De Psiquiatria 70(2):108116

Long-term human safety has not been formally established