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(b) oxidative stress including increased activity of pro-oxidative enzymes including myeloperoxidase (MPO) and oxidative damage as indicated by elevated production of malondialdehyde (MDA), protein carbonyls (PCs) and advanced protein oxidation products (AOPP)

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6.2.2 Excitotoxicity NO acts as a noncompetitive inhibitor of NMDAR, disrupting their regulatory role in synaptic plasticity, memory, and learning (Bae et al., 2022)