Levocarnitine is handled by several proteins in different pathways including carnitine transporters, carnitine translocases, carnitine acetyltransferases and carnitine palmitoyltransferases
(2014) This is one of the first papers showing that raising Klotho levels improves cognitive function in mice
doi: 10.1016/j.expneurol.2018.06.009 314 ShimataniK.NakashimaY.HattoriM.HamazakiY.MinatoN
Unlike conventional occupancy-driven inhibitors, PROTACs facilitate the selective degradation of target proteins, thereby offering an opportunity to achieve sustained and isoform-specific knockdown
The observed increase in oxytocin receptor expression in the anterior cingulate cortex of MIA mice suggests a potential neurobiological mechanism underlying these effects [1]
Inzucchi SE, Iliev H, Pfarr E, Zinman B (2018) Empagliflozin and assessment of lower-limb amputations in the EMPA-REG OUTCOME Trial