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Phase 2 NEJM titration (still common in research) Phase 2 retatrutide titration schedule Phase Initiation Weeks Weeks 1-4 Weekly Dose 1 mg Phase Early escalation Weeks Weeks 5-8 Weekly Dose 2 mg Phase Mid escalation Weeks Weeks 9-12 Weekly Dose 4 mg Phase High escalation Weeks Weeks 13-16 Weekly Dose 8 mg Phase Maximum Weeks Weeks 17+ Weekly Dose 12 mg Source: Jastreboff et al., NEJM 2023
If you are already experiencing symptoms at the starting dose, increasing will make them worse
What practical steps could the UK or EU Patent Offices take right now to review these massive patent portfolios critically, ensuring that strategic filing doesn't unduly restrict access for a drug class with such profound public health implications
Following his fellowship at Lilly, Tschp led a research team at the German Institute of Human Nutrition and then in 2003 became Professor of Endocrinology and Diabetes at the University of Cincinnati
Tirzepatide came off the FDAs official drug shortage list in December 2024, and semaglutide followed in February 2025, eliminating the legal pathway that allowed compounding pharmacies to produce copies of the drugs
Vctor et al., 2009)
