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Primary risk factors Clinical studies have pinpointed four key predictors of semaglutide-related side effects: Gender Women have approximately 2.3 times higher odds of experiencing GI side effects compared to men Advancing age Each additional year of age modestly increases risk History of gastrointestinal disorders This is the strongest predictor, increasing odds by more than 6-fold Polypharmacy Taking multiple medications simultaneously increases risk Does taking metformin worsen semaglutide side effects
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