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Agents such as orforglipron, a first-inclass, non-peptidyl GLP-1 RA, demonstrate that small-molecule scaffolds can achieve clinically meaningful glycemic and weight-lowering efficacy with once-daily oral administration [74]
Similarly, the FDA's reviews of the clinical trials, including large outcome studies and observational studies did not find an association between use of GLP-1 RAs and the occurrence of suicidal thoughts or actions
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However, the symptomatic overlap means that patients with IBS may find it challenging to distinguish between their baseline condition and medication-related side effects
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