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Injectable or intranasal routes do produce plasma-level exposure, though published human pharmacokinetic studies remain sparse compared with, say, GLP-1 receptor agonists

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456,457 Metformin mediates improved insulin sensitivity by increasing insulin receptor tyrosine kinase activity, enhancing glycogen synthesis, and increasing the recruitment and activity of the glucose transporter GLUT4

10.1016/j.juro.2015.01.086 74 HansenH