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Taken together, our results indicate that GIPR in the AP underlie the weight loss effects of GIPR agonism, whereas GIPR in the hypothalamus underlie the additional weight loss effects of adding GIPR antagonism to GLP-1R or amylin receptor agonism

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In studies examining the combination therapy of cagrilintide with semaglutide (known as CagriSema), a gradual dose-escalation approach was employed