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Through the modification and optimization of GLP-1, Novo Nordisk successfully synthesized this long-acting and stable GLP-1 RA, and confirmed the Its efficacy and safety as a drug for the treatment of type 2 diabetes
An assay based on the blockade of ovulation in cycling rats was used for testing antagonists 19 , and analogs such as [d-Phe2, d-Ala6]-LH-RH and [d-Phe2, d-Leu6]-LH-RH were able to block ovulation and the preovulatory surge of gonadotropin 19