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It's important to note that some diabetes medications, particularly SGLT2 inhibitors (such as dapagliflozin, empagliflozin) which are sometimes co-prescribed with tirzepatide, do directly increase urination as part of their mechanism of action
After subcutaneous administration, it circulates systemically, reaches multiple injury locations simultaneously, and modulates the inflammatory environment throughout the body rather than at a single point
Read more about Zepbound and sleep apnea at the Alliance of Sleep Apnea Partners blog
Switching medications may be considered if a patient experiences side effects, supply issues, or if a different treatment option is better suited to their needs
P MJ, Jurica J, Pov M, et al
In summary, the relatively higher expression of GLP-1R on -cells allows GLP-1 to indirectly inhibit glucagon secretion by promoting somatostatin secretion
