Weight loss from semaglutide or tirzepatide can trigger telogen effluvium, a temporary hair shedding condition affecting up to 10% of patients during rapid weight loss
Using a model of streptozotocin diabetes in rats in vivo and HT-22 cells in vitro, it was shown that GLP-1RA liraglutide improves the cognitive abilities of rats with diabetes mellitus and can have a protective effect by reducing oxidative stress, suppressing the expression of -secretase (BACE1) and -secretase, as well as reducing the deposition of -amyloid by triggering signaling mechanisms associated with NF-kB and ERK1/2 [30]
It also increases vascular flow to the tendons and ligaments to increase healing and can also help aid skin burns to heal faster and increase blood flow to damaged tissues
The brain atrophy of GCLC-KO mice was also evidenced by MRI analyses (Fig
Some patients prefer to start the regimen on a weekend for maximum appetite suppression, including less craving & food noise
Semaglutide uses much lower doses (0.25mg to 2.4mg), requiring different concentrations