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In patients using GLP-1s, retention of contents in the GI tract can lead to fermentation of gut contents, gas overproduction, and abdominal discomfort
There are predictions that 10-15% of the UK population could be taking these drugs by 2030, he says
The SURMOUNT-4 trial assessed the weight maintenance with tirzepatide and had also two periods: a 36-week open-label lead-in period during which all participants took tirzepatide, followed by a 52-week double-blind treatment period during which participants were randomised to either continue on tirzepatide or switch to placebo
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