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The appropriate amount depends on the form, reason for use, concurrent precursors, medical history and clinician guidance

The standard dosing schedule starts with 0.25 mg weekly for the first four weeks, increases to 0.5 mg weekly from weeks five through eight, and then may escalate to 1 mg or 2 mg weekly depending on tolerance and response

Here, we review the historical progress in the development of EGFR TKIs and on-target-mediated and EGFR -independent resistance mechanisms, aiming to summarize the current status of and provide future directions for EGFR TKI research

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10.1126/science.185.4154.862 Science