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People with MTHFR mutations almost always have low glutathione levels, making them more susceptible to stress and oxidative stress while making them far less tolerant to toxins
(PubMed) Boeke CE, Gillman MW, Hughes MD, Rifas-Shiman SL, Villamor E, Oken E
Nonenzymatic lysine d-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses
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