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Stronger mechanistic clarification would require isoform-specific NOS inhibition, direct measurement of NO metabolites, eNOS phosphorylation analysis, rescue experiments, and comparison across endothelial, epithelial, fibroblast, and neuronal model systems
Clinical Update 2/09/2026 Coffee, Tea & Dementia Risk A study showed a reduced risk of cognitive decline and dementia with coffee consumption, but not with all types and amounts of coffee
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