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doi:10.1016/s0301-0082(99)00008-8 Orr JE, Malhotra A, Sands SA
Using this dosing approach, senolytic therapies have been shown to reduce age-related senescent cell burden and improve vascular function with chronological aging, early aging, and CVD [Table 1]
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The TLR4-NF-B pathway is also inhibited by SSB2 in LPS-induced microglia, which suppresses the activation of microglia and reduces the levels of IL-1, IL-6, and TNF-, increasing the anti-inflammatory cytokine IL-10 (Wang et al., 2023)
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