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Category 2 These substances raised significant FDA safety concerns

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Additionally, keratinocytes and Langerhans cells (LCs), release cytokines such as IL-10, IL-12, IL-18, IL-23, IL-17 and IL-22 and thymic stromal lymphopoietin (TSLP), leading to an enhanced Th2-type inflammatory response (48, 50, 51)

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Research outcomes can vary by study design, conditions, and model used