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View Study [4]"Development of Cagrilintide, a Long-Acting Amylin Analogue" Kruse T et al., 2021 Finding: Describes the medicinal chemistry development of cagrilintide, explaining how lipidation extended the half-life from minutes (pramlintide) to approximately one week while maintaining receptor activity
doi: 10.1007/s11695-023-06484-8 30 KristensenSLRrthRJhundPSDochertyKFSattarNPreissDet al
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Oral Administration Most peptides cannot survive oral delivery the sequential barriers of stomach acid, intestinal enzymes, and first-pass liver metabolism degrade peptide bonds before they reach systemic circulation
58 Phase 2a trial of GSBR-1290 (120mg) in 40 healthy obese volunteers over 8 weeks demonstrated a significant reduction in BW (120 mg: -4.74%
However, real-life analyses indicate a higher discontinuation rate, of approximately 70% stopping within 2 years, especially in non-diabetic patients (112, 113)
