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In particular, UA may exert different effects depending on the chemical microenvironment and concentration, including antioxidant activity and pro-oxidant action [181]
Bibliography: 1 Stephens FB, Constantin-Teodosiu D, Greenhaff PL
[9] High-dose niacin (used to treat cholesterol) lacks human safety data in pregnancy and could theoretically affect the fetus (for example, by causing hypotension or altering lipid metabolism)
Cancer Res 85 , 1804 (2025)
These are analogs of GLP-1 with longer half-lives and sustained action, effectively enhancing insulin secretion and inhibiting glucagon release
Abbreviations GLP-1RAs: Glucagon-like peptide 1 receptor agonists GLP-1: Glucagon-like peptide 1 ADRs: Adverse drug reactions SSIBs: Suicidal or self-injurious behaviors EMA: European Medicines Agency FDA: The Food and Drug Administration FAERS: The Food and Drug Administration Adverse Event Reporting System MedDRA: The Medical Dictionary for Regulatory Activities TTO: Time-to-onset CI: Confidence interval IC: Information Component References Lingvay I, Leiter LA
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