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doi: 10.1038/s41531-020-0117-1 86 ManfreadyRAEngenPAVerhagen MetmanLSanzoGGoetzCGHallDAet al
Digestive enzyme supplements work locally in the gut to break down nutrients and do not interact pharmacologically with semaglutide's systemic GLP-1 receptor mechanism
The more aggressive approach is to start creatine immediately alongside tirzepatide, or to continue existing creatine supplementation when beginning the medication
long-term effects on NAD+ metabolism, liver function, and cardiovascular health are unknown
They can reduce appetite
None of these are GLP-1-specific, and their effects are individually small
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