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Orforglipron is under assessment for the management of obesity and T2D and may provide a competitive alternative to oral semaglutide, with less burdensome administration, as it does not require to be taken at a fasting state [24]

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In Phase 2 and early Phase 3 trials, the most common side effects were gastrointestinal, including nausea, diarrhea, vomiting, and constipation, which were generally mild-to-moderate and dose-dependent

Our findings indicate that agomelatine exhibits its agonist activity at melatonin receptors MT1 and MT2 [59] whilst prompting norepinephrine and dopamine release by antagonising serotonergic 5-HT2C receptors [59]