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For patients concurrently using weight-management peptides, which undergo hepatic metabolism, genetic insights into Phase II capacity may help providers anticipate medication tolerance and accumulation risk more effectively

[5] Growth Hormone Receptor Upregulation BPC-157 increases growth hormone receptor expression in multiple tissue types in laboratory studies

doi: 10.1016/j.cell.2023.11.037 63 KimGHFangXQLimWJParkJKangTBKimJHet al

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Whether adding cagrilintide preserves more lean mass than retatrutide alone or whether the added satiety drives more lean-mass loss by reducing protein intake further is unknown