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This gap is especially consequential in neurological disease, where disability, frailty, pain, and comorbidity disproportionately constrain the populations most likely to benefit from exercise-induced adaptations
Most treatments target one mechanism
In addition to the well-characterized catalytic activity, recent evidence has shown that certain GST isozymes can regulate mitogen-activated protein kinases or can facilitate the addition of glutathione to cysteine residues in target proteins ( S -glutathionylation)
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