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Based on the fact that the carboxyl moiety of ibuprofen binds to Arg-120 and Tyr-355 without extending into the side pocket, it was hypothesized that making the carboxyl group longer by adding larger, more rigid groups with hydrogen-bonding functions could enhance the selectivity of ibuprofen while maintaining its ability to reduce pain and inflammation
Taken together, numerous studies have confirmed the importance of chemokines in APAP-induced hepatotoxicity and repair progression, which may provide hope for specific treatment of the disease
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Cellular senescence or stemness: hypoxia flips the coin
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