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Because the previous dose hasnt fully cleared your system, the new dose pushes the total concentration higher than intended
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If features of Cushing's syndrome are present (such as central weight gain, easy bruising, or stretch marks), an endocrine referral may be appropriate
Its making sure the treatment is delivered safely, by qualified professionals, with a proper health intake and realistic expectations about timeline
However, meaningful, clinically significant weight loss typically defined as 5% of baseline body weight, a threshold referenced in NICE guidance on the management of overweight and obesity generally becomes apparent between weeks 8 and 12 , particularly as the dose is gradually escalated according to the trial protocol
In addition to treating the cardiac stresses that occur with obesity and associated morbidities, such as OSA, additional cardiovascular benefits of GLP-1s are thought to be mediated by their action on vascular smooth muscle cells and endothelial cells
Pancreatitis: There have been reports of acute pancreatitis with GLP-1 receptor agonists and tirzepatide
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