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doi: 10.3389/fimmu.2022.1098243 9 OnoM

Creatine is therefore relevant to both low-SAM and high-SAH patterns, though response depends on kidney function, hydration, dose, diet and the broader clinical picture

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Science 324 , 651654 (2009)

Despite the role of gut microbiota in the modulation of dopamine and norepinephrine remains to be fully understood, germ-free (GF) animal models have shown that there is a noteworthy alteration of these neurotransmitters in the gut as well as in the brain, which could have important consequences in the behavior [178]