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Informed consent was obtained from all individual participants included in the study

According to data from JAMA Health Forum, semaglutide (the GLP-1 molecule) saw 2.6 million retail prescriptions filled by Dec 2023 in the U.S

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The pathophysiologic rationale is robust, targeting the neurogenic inflammation and central sensitization propagated by the trigeminovascular system, and the preliminary clinical data demonstrate safety and efficacy

Xu, Association of semaglutide with risk of suicidal ideation in a real-world cohort