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In a Phase III trial in patients 6 to 12 years, the drugs pharmacokinetic and pharmacodynamic profiles were consistent with that seen in previous studies, according to AstraZeneca
Efficacy and safety of GLP-1 receptor agonists as add-on to SGLT2 inhibitors in type 2 diabetes mellitus: a meta-analysis
This approach allows the synthesis of large proteins, since it is based in the production of different unprotected linear peptide fragments, which are condensed in solution via chemoselective reactions to originate the entire polypeptide (Kent et al., 2012)
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Cell Death Dis 17 , 358 (2026)
The overall evidence supports a favorable hepatic safety profile, with potential therapeutic benefits for patients with underlying liver disease related to metabolic syndrome
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