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In the SUSTAIN 3, 7, and 10 trials, semaglutide was found to be superior to other GLP-1RAs at lowering glycated hemoglobin and body weight

Patients taking retatrutide whether within a clinical trial setting or otherwise should be aware of the circumstances that warrant prompt medical review

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Monitor blood glucose and IGF-1 levels if using extended protocols

Another review looking at berberine for reducing cardiovascular disease risks found that it reduced weight compared to a placebo (inactive pill)