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This creates a devastating feedback loop: mast cells release histamine, which causes systemic inflammation

doi:10.1097/j.pain.0000000000001474

(Maywood) 233, 881890

We established a D-galactose-induced aging model in randomly selected male and female mice through intraperitoneal injections of D-galactose (200 mg/kg/day, MCE, HY-N0210), starting at 8 weeks of age for 8 weeks