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Additionally, for the cerebrovascular uptake study treatment was added as repeated variable

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Although the exact mechanism of action is not fully understood, it is hypothesised that bupropion stimulates hypothalamic pro-opiomelanocortin (POMC) cell, with downstream effects to reduce food intake and increase energy expenditure

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The goal is to stimulate blood flow, engage your muscles, and release endorphinsnot to exhaust yourself further