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These therapies also come with tradeoffs, including gastrointestinal side effects and the potential for nutrient gaps if food intake drops too low
Introducing steric blockade has proven a successful strategy to increase the stability of a peptide in vivo but typically this has been at the expense of potency, as for instance a 48-fold difference at human GLP-1R in transfected CHO cells between Ab#2_DSB#1 and the same molecule without the disulphide bridge (Ab#2_EX4)
Asymptomatic gallstones do not automatically prevent semaglutide therapy, but symptomatic disease requires medical evaluation first
Beyond that, the precise mechanism resulting in a reduction of inflammation remains to be described
Zeya Xie Z et al
It's worth noting that severe abdominal pain is not a typical 'flu-like' symptom and could indicate more serious conditions such as pancreatitis or gallbladder disease, which are rare but recognised complications of GLP-1 therapy
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