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On average, patients using tirzepatide lost 50.3 lbs (22.8 kg), and those using semaglutide lost 33.1 lbs (15.0 kg) after 72 weeks

Specifically, SHANK3 plays a pivotal role in regulating glutamatergic synapses, maturation of the dendritic spine, and strengthening the formation and transmission of synapses via glutamate receptors such as AMPARs and NMDARs

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