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Johnson, W.M., A.L

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The usual amount of vitamin B12 needed is 2.4 micrograms (mcg) for adults

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Since B12 is water-soluble, your body excretes what it doesnt use, making it generally safe, even in higher doses [*]

However, it should be possible if needed by measurement of gamma-glutamylcysteine synthetase activity or mutational analysis (if the mutation in the family is known) of chorionic villi or cultured amniocytes