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Semaglutide is a GLP-1 receptor agonist that slows gastric emptying, reduces appetite, and increases feelings of fullness
While the nephroprotective effects of SGLT2i were initially derived from secondary endpoints of CV outcome trials (CVOTs), direct confirmation came from dedicated kidney focused trials: CREDENCE (Perkovic et al NEJM 2019| NephJC Summary), DAPA-CKD (Heerspink et al NEJM 2020| NephJC Summary) and finally EMPAKIDNEY (Herrington et al NEJM 2023| NephJC Summary)
Reacciones en el sitio de inyeccin: Dolor, enrojecimiento o irritacin en el sitio de inyeccin son independientes del horario, pero la administracin matutina permite observar cualquier reaccin durante el da
Many patients report that symptoms are most pronounced in the 1-3 days following their weekly injection, then gradually improve as the week progresses
This creates equal pressure, making it easier to draw the liquid out
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